MCQS From Past Papers of Hospital Pharmacist 👨⚕️
101.In IR spectroscopy, OH-bond is represented by?a.Single peak
b.Double peak
c.Sharp peak
d.Thick band
Ans: [D]
102. Non-polar compounds used in IR spectroscopy are?
a.CS2 & CO2
b.CS2 & HCL
c.CS2 & CCL
d.All of the above
Ans: [D]
Note: But not commonly used now.
103.Alkyl halides cause Itching in form?
a.Solid
b.Liquid
c.Semi-solid
d.Gaseous
Ans: [B]
104.Gelatin Is obtained by treating collagen with?
a.Weak acid
b.Weak alkali
c. Acid
d.Both A & B
Ans: [D]
Note: Type-A Gelatin (Acidic) & Type-B Gelatin (Basic).
105. Eggs of Calandra granaria feed on parts of plants?
a.Carbohydrates
b.Lipids
c.Starch
d.Dead
Ans: [A]
Note: It feeds on seeds and grains of plants.
a.Increases
b.Decreases
c.No change
d.Slightly increases
Ans: [A]
107.Most common bond between a drug and its receptor is?
a.Hydrogen
b) Covalent
c) lonic
d) Electrostatic
Ans: [D]
108. Attachment of drug to its complementary receptor is based on?
a.Density
b.Structure
c.Bonding
d.Shape
Ans: [B]
109.Concentration of drug at receptor site determines its?
1. Efficacy Il. Potency III. Toxicity
a. I only
b. ll only
c. I & lll only
d. l,ll & lll
Ans: [C]
110.For organoleptic drug evaluation, drug is spread on paper?
a.About 10g
b.About 20g
c.150-250g
d.250-500g
Ans: [A]
111.A decrease in blood pressure by 5 mmHg is a. change?
a.Positive
b.Negative
c.Input
d.Output
Ans: [A]
112.How many steps are involved In product development?
a.5
b.7
c.8
d.9
Ans: [A]
Note: Discovery & Development, Preclinical Research, Clinical,Research, FDA Drug Review & FDA Post-Marketing Drug Safety Monitoring.
113.The "islet-vein" in plants is near the point of?
a.Photosynthesis
b.Respiration
c.Oxidation
d.Reduction
Ans: [B]
114.Fibers are Invisible in?
a.Phenol
b.Water
c.Chloral hydrate
d.Lactophenol
Ans:[C]
115.Hydrolysis of a drug can lead to?
a.Instability of drug product
b.Color change in drug product
c.Loss of therapeutic activity
d.All of the above
Ans: [D]
116.Pregnancy category of penicillin according to FDA is?
a.X
b.D
c.C
d.B
Ans: [D]
117.Thiazide diuretics are NOT likely to cause?
a.Hypokalemia
b.Hyponatremia
c.Hypernatremia
d.Hypotension
Ans: [C]
118.Aripiprazole acts as partial agonist at receptors?
a.Cholinergic
b.Adrenergic
c.Dopaminergic
d.Serotonergic
Ans: [C]
119.Anti-staphylococcal penicillins are also called?
a.Acid resistant penicillins
b.Alkali resistant penicillins
c.Penicillinase-resistant penicillins
d.Penicillinase-sensitive penicillins
Ans:[C]
120.Drugs are packed in container along
with?
a.Reducing agent
b.Oxidizing agent
c.Wetting agent
d.Desiccating agent
Ans: [D]
121.Parts of parenteral products Include?
a.Lid
b.Seal
c.Container
d.All of the above
Ans: [D]
122.Which part of aerosol preparation ensures uniform dose?
a.Dip Tube
b.Gasket
c.Actuator
d.Propellant
Ans:[C]
123.Process of obtaining clear liquid after settling of particles is called?
a.Decantation
b.Distillation
c.Filtration
d.Sedimentation
Ans: [A]
124.Which of the following phase changes occur during distillation?
a.Solid -> Liquid - Vapor
b.Vapor -> Liquid -+ Solid
c.Liquid -+ Vapor -+ Liquid
d.Vapor -+ Liquid -+ Vapor
Ans:[C]
125.FSH and ACTH hormones are?
a.Steroids
b.Sterols
c.Glycoproteins
d.Metalloproteins
Ans: [C]
126.Cholesterol Is precursor for the synthesis of?
a.Steroids
b.Thyroid hormones
c.Pituitary hormones
d.Pancreatic hormones
Ans: [A]
127.Which enzyme destroys tissues during necrosis?
a.Hyaluronidase
b.Trypsin
c.Chymotrypsin
d.Bromelain
Ans: [A]
128.Absorption of calcium is enhanced by ?
a.Vitamin D
b.Vitamin C
c.Vitamin A
d.Vitamin B
Ans: [A]
129.Percentage occurrence of ADRs is?
a.10%
b.20%
c.30%
d.40%
Ans: [B]
130.Majority of medication errors in UK occur during?
a.Diagnosis
b.Prescribing
c.Administration
d.Treatment
Ans: [C]
131.Anti-Parkinsonlan effects of levodopa may be antagonized by?
a.Dihydrotachystero!
b.Tocopherol
c.Niacinamide
d.Pyridoxine
Ans: [D]
132.Which of the following stops replication of bacteria?
a. All antibiotics
b. Bactericidal
c. Bacteriostatic
d. All of the above
Ans: [C]
133.Conversion of solid into liquid by heating is called?
a.Boiling
b.Fusion
c.Vaporization
d.Sublimation
Ans: [B]
134.A drug can cross blood-brain barrier if It is ?
a.Hydrophilic
b.Lipophilic
c.lonized
d.All of the above
Ans: [B]
135.Difference between Minimum Effective Concentration (MEC) and Minimum Toxic Concentration (MTC) Is called?
a.Therapeutic Window
b.Therapeutic Dose
c.Toxic Window
d.All of the above
Ans: [A]
136.Ratio of Median Toxic Dose (TD50) and Median effective Dose (ED50) is called?
a.Toxic Range
b.Effective Range
c.Therapeutic Range
d.Therapeutic Index
Ans: [D]
137.Catgut sutures are manufactured from the intestine of?
a.Cat
b.Sheep
c.Horses
d.Deer
Ans: [B]
138.Antagonistaffects a drug's?
a.Potency
b.Efficacy
c.Safety
d.Toxicity
Ans: [B]
139.Efficacy and safety of a drug depends on its at receptor site?
a.Density
b.Concentration
c.Volume
d.Mass
Ans: [B]
140.Hydrophobic bonds are helpful In which process?
a.Dissolution
b.Solvation
c.Hydration
d.Repulsion
Ans: [D]
141.Amides, ether and alkanes are examples of?
a.Hydrolysable bonds
b.Non-hydrolysable bonds
c.Organic functional groups
d.Organic families
Ans: [D]
142.Drug degradation is quickest in?
a.Tablets
b.Solutions
c.Suspensions
d.Emulsions
Ans: [B]
143.Sulfonamides are drug of choice for which indication?
a.Urinary Tract Infections
b.Respiratory Tract Infections
c.Abdominal Infections
d.Tuberculosis
Ans: [A]
144.Which of the following is antidote of dopamine?
a.Phentolamine
b.Tizanidine
c.Cimetidine
d.Reserpine
Ans: [A]
145.Ethosuximide belongs to which pharmacological class?
a.Anti-Parkinsonian
b.Anti-Epileptic
c.Anti-Hypertensive
d.Hypnotic
Ans: [B]
146.Estazolam belongs to which pharmacological class?
a.Barbiturates
b.Benzodiazepines
c.Phenothiazines
d.General Anesthetics
Ans: [B]
147.Which one of the following is longacting barbiturate
a.Thlopental Sodium
b.Secobarbital
c.Pentobarbital
d.Phenobarbital
Ans: [D]
148.Antidote of Physostigmine is?
a.Atropine
b.Pilocarpine
c.Edrophonium
d.Neostigmine
Ans: [A]
149.According to USP-NF, dissolution testing of enteric coated diclofenac tablets Is carried out using which apparatus?
a.Apparatus 2: Paddle Method
b.Apparatus 3: Reciprocating Cylinder
c.Apparatus 4: Flow Through Cell
d.Apparatus 5: Paddle Over Disk
Ans: [A]
Note: Apparatus 1 (EC Aspirin) & Apparatus 2 (EC Diclofenac).
150. Local anesthetics are?
a.Weak acids
b.Weak bases
c.Strong bases
d.Neutral
Ans: [B]
151.Phenytoin and Valproic Acid are classified as?
a.Anxiolytics
b.Anti-convulsants
c.Anti-diabetics
d.Anti-parkinsonian
Ans: [B]
152.Weight variation in tablets affects which of the following?
a.Counting & Storage
b.Packaging & Transportation
c.Packaging & Storage
d.Counting & Transportation
Ans: [B]
153.In stable-angina, coronary blockade is up to?
a.20%-30%
b.40%-50%
c.60%-70%
d.280%
Ans: [C]
154.One liter of 2% glucose solution contains grams of sugar?
a.2g
b.20g
c.200g
d.2 Kg
Ans: [B]
155.Bretylium has which of the following side effect?
a.Constipation
b.Faintness
c.Teeth discoloration
d.Urinary retention
Ans: [B]
Note:BretyliumIs Class-Ill antiarrhythmic drug that blocks neuronal noradrenaline release.
156. In Type-1 hyperlipidemia, which of the following risk is involved?
a) Low risk of IHD
b) Moderate risk of IHD
c) High risk of IHD
d) Risk of pancreatitis
Ans: [C]
Note:Elevated chylomicrons In type-1 hyperlipidemia are highly atherogenic lipoproteins.
157. Gastro-Esophageal Reflux Disease (GERD) may lead to which severe complication?
a.Peptic Ulcer
b.Barrett's Esophagus
c.Diabetes Mellitus
d.Bloody Diarrhea
Ans: [B]
Note: Aspiration of acid into lungs may also occur.
158.Alpha-antagonists are considered as alternate antihypertensives to ẞ1 blockers in which co-morbid condition?
a.Hyperlipidemia
b.Angina Pectoris
c.Thrombosis
d.Diabetes
Ans. [A]
Note: Alpha1-antagonists may increase HDL and decrease LDL & total cholesterol.
159.Folic acid antagonizes the effects of which drug?
a.Ciprofloxacin
b.Co-Trimoxazole
c.Metronidazole
d.Paracetamol
Ans:[B]
160.Pigmentation of hydrophobic intra ocular lens (IOL) occurs due to which eye drops?
a.Steroidal eye drops
b.Anti-glaucoma eye drops
c.Antibiotics eye drops
d.Antihistaminic eye drops
Ans: [B]
Note: Anti-glaucoma eye drops containing prostaglandin analogs.
161.Particlesize ofcolloidal system is?
a.0.01 - 1 nm
b.1- 100 nm
c.10 - 1000 nm
d.1 nm - 1 um
Ans: [D]
162.Milk is which type of colloidal system?
a.Lyophobic colloid
b.Lyophilic colloid
c.Association colloid
d.Suspension
Ans: [B]
Note: Sub-type of milk colloidal system is emulsion.
163.Na2CO3 has how many water molecules?
a.1
b.2
c.5
d.10
Ans: [D]
164.Molecular weight of polymers Is measured by which method?
a.Gas Chromatography - Mass Spectroscopy
b.Fourier Transform Infrared Spectroscopy
c.Gel Permeation Chromatography
d.Gel Filtration Chromatography
Ans: [C]
165.Method best suited for separation of rectified spirit to prepare absolute alcohol is?
a.Zeotropic distillation
b.Azeotropic distillation
c.Steam distillation
d.Destructive distillation
Ans: [B]
166.Morphine solution is decomposed by?
a.High pH
b.Heat
c.Oxygen
d.Both a & c
Ans: [D]
167.FeCl3 water system is?
a.Two phase system
b.Has congruent melting point
c.Bothe of these
d.None of these
Ans: [C]
168.Best method to purify colloidal system?
a.Dialysis
b.Sublimation
c.Distillation
d.Chromatography
Ans: [A]
Note: Other methods include electrodialysis, ultra-filtration, electrodecantation etc.
169.Accelerated stability studies are carried out at?
a.30c+-2C and 65 + 5 % RH
b.40c+-2C and 65 + 5 % RH
c.40c+-2? C and 75 + 5 % RH
d.50c+-2? C and 65 + 5 % RH
Ans: [C]
170.GPP guidelines?
a.Good Pharmacy Practices
b.Good Participatory Practices
c.Good Pharmacoepidemiology Practices
d.All of the above
Ans: [D]
171.Most members of soil fauna are?
a.Vertebrates
b.Invertebrates
c.Both of theses
d.None of these
Ans: [B]
172.Function of hypodermis is?
a.Structural support
b.Insulation
c.Shock absorber
d.All of the above
Ans: [D]
173.During exercise, hyperemia in muscles is caused by?
a.Tachycardia
b.Vasoconstriction
c.Vasodilation
d.All of the above
Ans:[C]
174.protease derived from Bacillus subtilis is used in laundry?
a.Acidic
b.Alkaline
c.Neutral
d.Amphoteric
Ans: [B]
175.Which disorder is associated with tyrosine?
a.Tyrosinemia
b.Neurotransmitter disorders
c.Metabolic disorder
d.All of the above
Ans: [D]
176.Esterification test is used for?
a.Acidic catalysis
b.Basic catalysis
c.Neutral catalysis
d.All of the above
Ans: [A]
177.Tertiary alcohols are resistant to
oxidation because they?
a. Lack C-C bond atcarbon attached to OH
b.Lack C-H bond atcarbon attached to OH
c.Lack C-N bond atcarbon attached to OH
d.Lack C=O bond atcarbon attached to OH
Ans: [B]
178.Ethanol can be oxidized to?
a.Formaldehyde
b.Acetaldehyde
c.Acetone
d.All of the above
Ans: [B]
179.Bubble point test is used?
a.To determine Integrity of membrane filters
b.To determine the efficiency of chromatographic column
c.To check the leakage in glass ampoules
d.To check the contamination of liquid dosage forms
Ans: [A]
180.Suitable temperature to grow for pathogens is?
a.0- 15 C
b.4-25 C
c.20-45 C
d. More than 50 C
Ans: [C]
Note: Most human pathogens are mesophiles.
181.Operating speed for dissolution of suspension is?
a.15 RPM
b.25 RPM
c. 40 RPM
d.50 RPM
Ans: [B]
182.Which method is used for sterilization of IV fluids?
a.Ethylene Oxide Sterilization
b.ionizing Radiations
c.Moist Heat Under Pressure
d.Dry Heat Without Pressure
Ans: [C]
183.Most organic hydrogelsare_ phase systems?
Single
b) Two
c) Three
d) Four
Ans: [A]
184.Trichloromonofluoromethane Is commonly known as?
a.Propellant-11
b.Freon-11
c.Both of these
d.None of the above
Ans: [C]
185.If angle of repose Is less than 20, flow will be?
a.Poor
b.Normal
c.Intermediate
d.Excellent
Ans: [D]
186.Macerare is Greek word that means?
a.To eat
b.To chew
c.To destroy
d.To drink
Ans: [B]
187.lon exchange chromatography is based on?
a.Electrostatic attraction
b.Electrical mobility of lonic species
c.Adsorption chromatography
d.Partition chromatography
Ans: [A]
188.For typical adsorbent like silica gel, most appropriate pore diameter is?
a.10 to 50 Ao
b.60 to 100 Ao
c.100 to 150 Ao
d.150 to 200 Ao
Ans: [B]
189.In reverse phase HPLC, there is?
a.Non-polar solvent / polar column
b.Polar solvent / non-polar column
c.Non-polar solvent / non-polar column
d.All of the above
Ans: [B]
190.For a molecule to absorb IR radiations, molecule's vibrations must cause fluctuations in dipole moment of the molecule because?
a.Change in dipole moment lowers the energy required for electronic transitions
b.For absorption to occur, radiations must interact with electronic field produced by changing dipole moment
c.Fluctuations in the dipole moment allow the moleculeto de form by stretching or bending
d.All of the above
Ans: [C]
191.Fluorescence occurs when molecule?
a.Returns to electronic ground state from excited triplet state by losing energy
b.Returns to electronic ground state from excited singlet state by losing energy
c.Lowers its vibrational energy by losing excess energy as photons
d.None of the above
Ans: [B]
192.Which of the following detectors give concentration dependent signals?
a.Electron Capture Detector
b.Thermal Conductivity Detector
c.Infra-Red Detector
d.All of the above
Ans: [D]
193.Choose the CORRECT statement about gas chromatography?
a.May be used to analyze gases
b.May be used to analyze solids
c.May be used to analyze solutions
d.All of the above
Ans: [D]
194.Helium is generally preferred as carrier gas over nitrogen and hydrogen because?
a.Helium is inert
b.Helium has lowest viscosity
c.Doubles-up as party gas for balloons & funny voices
d.All of the above
Ans: [D]
195.In , column chromatography, the benefit of decreasing column internal diameter is?
a.Increased sample capacity
b.Increased resolution
c.Reduced risk of column overloading
d.All of the above
Ans: [D]
196.Which of the following is NOT used as stationary phase in gas chromatography?
a.Polysiloxanes
b.Cyclodextrins
c.Silica
d.None of the above
Ans: [D]
197.Which of the following is NOT a justification for use of excipients in drug products?
a.Excipients stabilize the API, preventing Its degradation before use
by.Excipients reduce the irritation caused by the API
c.API is too potent to be used undiluted, so excipients are necessary
d.Excipients exert pharmacological action along with API
Ans: [D]
198.Which of the following is an example of chemical modification of Active Pharmaceutical redient (API)?
a) Combining basic API with citric acid to produce citrate salt
b.Converting crystalline API into amorphous form
c.Mixing poorly soluble API with water to produce a suspension
d.Mixing freely soluble API with water to produce a solution
Ans: [A]
199.Pressure of 1 atm is equal to 101325 Pascal (Pa) or?
a.0.101325 MPa
b.1.01325 MPa
C.10.1325 KPa
d.101.325 KPa
Ans: [A]
200.Select diluent, disintegrant, binder & glidant in sequence?
a.Lactose, microcrystalline cellulose, sodium starch glycolate, magnesium stearate
b.Lactose, sodium starch glycolate, polyvinyl-pyrrolidone (PVP ) . colloidal silica
c.Calcium carbonate, colloidal silica, talc, magnesium stearate
d.Calcium carbonate, sodium starch glycolate, talc, microcrystalline cellulose
Ans: [B]
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